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Hormone Replacement Therapy
HRT Health Risks - Non-Hodgkin's Lymphoma

What is Non-Hodgkins Lymphoma?

Lymphoma is an abnormal growth of lymph tissue, usually malignant, that occurs within some part of the lymphatic system. The lymphatic system is a network of cells and organs that function as part of the body's immune system. This network includes the lymph nodes, lymph vessels, lymph fluid, lymphocytes (small white blood cells that circulate in the body), spleen, bone marrow, tonsils and thymus gland. The lymphatic system fights infection and provides protection from disease.

Lymphomas are broadly classified into two main groups: Hodgkins lymphoma and Non-Hodgkins lymphomas (NHL). A study published in 2002 concluded that women taking hormone replacement therapy (HRT) were at greater risk for developing a particular type of non-Hodgkins lymphoma (NHL) - see discussion below.

Non-Hodgkins lymphoma (NHL) is a group of many different diseases that affect the lymphatic system. These many different diseases are divided into two groups depending on the type of lymphocytes (white blood cells) that are implicated in the disease:

  • B-cell lymphomas - those lymphomas that develop from abnormal "B-cell" lymphocytes;
  • T-cell lymphomas - those lymphomas that develop from abnormal "T-cell" lymphocytes.
Lymphomas are also categorized as either Aggressive or Indolent. Aggressive lymphomas are intermediate to high-grade tumors that spread and grow quickly. Indolent lymphomas are low grade tumors that tend to grow slowly.

NHL and Hormone Replacement Therapy (HRT)

In 2002, Cerhan, J. et al reported the results of their study of 37,220 women living in Iowa with no prior history of cancer. The results of the study, published in the November, 2002 issue of Cancer Epidemiology Biomarkers and Prevention, concluded that women taking hormone replacement therapy (HRT) were at greater risk for developing a particular B-cell type of non-Hodgkins lymphoma known as Follicular Cell Lymphoma, particularly the Nodal form of the disease. Nodal Follicular Cell Lymphoma involves clusters of cancerous B-cells within a lymph node. This type of non-Hodgkins lymphoma tends to be indolent or low-grade, i.e. slow-growing.

The strongest association between Follicular Cell Lymphoma and hormone replacement therapy occurred in women who were current users estrogen-only HRT (drugs like Premarin and Estradiol) - a 3.3 increase in risk over women who had never used HRT. For women who were current uses of estrogen-only HRT for more than 5 years, there was a 3.9 times greater risk than those who never used HRT. For former users of estrogen-only HRT, the risk was 2.6 times greater.

If you or a loved one developed Non-Hodgkins Lymphoma after using hormone replacement drugs such as Prempro®, Provera®, Premphase®, Premarin, Estradiol, FemHRT® or the generic medroxyprogesterone acetate (MPA), and would like to learn more about your legal rights, please click here.



Please click here if you or a loved one used Hormone Replacement Therapy (HRT) medications and suffer from:

  • Breast Cancer
  • Ovarian Cancer
  • Non-Hodgkin's Lymphoma
  • Gall Bladder Cancer



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